ABSTRACT
Objective: to describe the clinical presentation and outcomes of COVID-19 in lung transplant recipients (LTRs) when managed with high-dose corticosteroids along with standard therapy. Method(s): all nine (9) adult LTRs with confirmed SARS-CoV-2 infection and chest X-ray with predominant bilateral infiltrates and hypoxemia, treated with high-doses corticosteroids similar to an acute rejection treatment were included. All our treated patients presented acute respiratory failure and bilateral pulmonary infiltrates. Result(s): six (6) out of nine (9) patients (66%) treated with bolus evolved favorably. Patients without corticosteroids treatment and severe disease died. Despite lymphopenia and methylprednisolone pulse therapy there were no infectious complications. As per protocol antiviral, bacterial and fungal prophylaxis was prescribed during this period. RT- PCR took long time in becoming negative. Patients who received megadoses of corticosteroids were more likely to live than those who received low doses Conclusion(s): COVID-19 in lung transplant recipients with acute respiratory failure presents a favorable outcome when is managed with high-doses corticosteroids along with standard therapy.